Clinical use of dopamine antagonist sulpiride to advance first ovulation in transitional mares
Theriogenology, ISSN: 0093-691X, Vol: 75, Issue: 1, Page: 138-143
2011
- 24Citations
- 52Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef19
- Captures52
- Readers52
- 52
Article Description
Artificial photoperiod treatment is currently the best method to hasten the first ovulation of the breeding season in winter anoestrus mares. However, this is not easy to apply in large herds of mares and, to be effective, has to be planned in the northern hemisphere in December at the latest. Pharmacological treatments have been proposed as alternatives: GnRH agonists, progesterone or its synthetic agonist Altrenogest, and dopamino-antagonists, as pherphenazine, domperidone or sulpiride. Dopamino-antagonists protocols, beginning at a given day of the year, gave controversial results in terms of hastening ovulation. The aim of this study was to evaluate the efficacy of an up-to-21-d long dopamine antagonist (sulpiride) treatment on mares at the beginning of the spring transition for its ability to hasten estrous cyclicity. In Study 1, 49 seasonally-acyclic standardbred mares, maintained in paddocks under natural photoperiod, were treated with 1 mg/kg/d sulpiride at the evidence of the first follicle with of 25 mm in diameter until ovulation for a maximum of 21 d (Group S 1 ; n = 34) or left untreated (Group C 1 ; n = 15). Group S 1 and C 1 mares showed a follicle of 35 mm in diameter after 8 and 22 d (median; P < 0.05) and ovulated after 18 and 43 d, respectively (median; P < 0.05). Twenty-two/26 and 6/15 mares of the Group S 1 and C 1 ovulated within 30 d from the beginning of the treatment, respectively (P < 0.05). All the mares of the study cycled until Autumn, unless they became pregnant.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0093691X10004127; http://dx.doi.org/10.1016/j.theriogenology.2010.07.019; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78649891583&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20875676; https://linkinghub.elsevier.com/retrieve/pii/S0093691X10004127; https://dx.doi.org/10.1016/j.theriogenology.2010.07.019
Elsevier BV
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