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Fatty acid balance regulates α-synuclein pathology

Trends in Neurosciences, ISSN: 0166-2236, Vol: 45, Issue: 6, Page: 417-418
2022
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Fatty acid balance regulates α-synuclein pathology.

Trends Neurosci. 2022 Apr 1; Authors: Cohen-Adiv S, Ashkenazi A PubMed: 35379479 Submit Comment

Article Description

A recent study by Tripathi et al. used a protein engineering approach to demonstrate that cellular stress caused by familial α-synuclein mutations can be alleviated by altering the monounsaturated fatty acid equilibrium in neuronal cells. This work supports the notion that metabolic perturbation of lipids may be involved in the pathogenesis of Parkinson's disease.

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