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Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin

Toxicology Letters, ISSN: 0378-4274, Vol: 220, Issue: 3, Page: 259-266
2013
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Article Description

To assess P-glycoprotein (P-gp)-modulation ability and the mechanisms of P-gp inhibition mediated by a new synthetic rifampicin derivative, 1,8-dibenzoyl-rifampicin (DiBenzRif), in an in vitro model of the blood–brain barrier (BBB), RBE4 cells, and in membrane mimetic models (liposomes).

Bibliographic Details

Vilas-Boas, Vânia; Silva, Renata; Nunes, Cláudia; Reis, Salette; Ferreira, Luísa; Vieira, Cátia; Carvalho, Félix; Bastos, Maria de Lourdes; Remião, Fernando

Elsevier BV

Pharmacology, Toxicology and Pharmaceutics

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