β1 integrin expression by podocytes is required to maintain glomerular structural integrity
Developmental Biology, ISSN: 0012-1606, Vol: 316, Issue: 2, Page: 288-301
2008
- 153Citations
- 103Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations153
- Citation Indexes153
- 153
- CrossRef127
- Captures103
- Readers103
- 103
Article Description
Integrins are transmembrane heteromeric receptors that mediate interactions between cells and extracellular matrix (ECM). β1, the most abundantly expressed integrin subunit, binds at least 12 α subunits. β1 containing integrins are highly expressed in the glomerulus of the kidney; however their role in glomerular morphogenesis and maintenance of glomerular filtration barrier integrity is poorly understood. To study these questions we selectively deleted β1 integrin in the podocyte by crossing β1 flox/flox mice with podocyte specific podocin-cre mice (pod-Cre), which express cre at the time of glomerular capillary formation. We demonstrate that podocyte abnormalities are visualized during glomerulogenesis of the pod-Cre;β1 flox/flox mice and proteinuria is present at birth, despite a grossly normal glomerular basement membrane. Following the advent of glomerular filtration there is progressive podocyte loss and the mice develop capillary loop and mesangium degeneration with little evidence of glomerulosclerosis. By 3 weeks of age the mice develop severe end stage renal failure characterized by both tubulointerstitial and glomerular pathology. Thus, expression of β1 containing integrins by the podocyte is critical for maintaining the structural integrity of the glomerulus.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0012160608000390; http://dx.doi.org/10.1016/j.ydbio.2008.01.022; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41149083878&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18328474; https://linkinghub.elsevier.com/retrieve/pii/S0012160608000390
Elsevier BV
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