Protein kinase C differentially inhibits muscarinic receptor operated Ca 2+ release and entry in human salivary cells
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 152, Issue: 3, Page: 1062-1069
1988
- 28Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations28
- Citation Indexes28
- CrossRef28
- 23
- Captures4
- Readers4
Article Description
We investigated the effects of phorbol myristate acetate on muscarinic receptor-induced Ca 2+ release from intracellular stores and extracellular entry in a human salivary duct cell line, HSG-PA. Phorbol myristate acetate (∼10 −7 M) blocked both Ca 2+ release and Ca 2+ entry induced by the muscarinic agonist carbachol. This blockade was the result of the activation of protein kinase C since 4α-phorbol 12,13-didecanoate, which lacks the ability to activate protein kinase C, did not inhibit Ca 2+ mobilization responses to carbachol. Importantly, at lower phorbol myristate acetate concentrations (∼10 −9 M), carbachol-induced Ca 2+ released was blocked, but carbachol-induced Ca 2+ entry was maintained. These results show that carbachol-induced Ca 2+ entry does not occur via an intracellular store and that protein kinase C plays a role in a feedback control mechanism for muscarinic-induced Ca 2+ mobilization at different levels.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X88803929; http://dx.doi.org/10.1016/s0006-291x(88)80392-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023894995&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/3377766; http://linkinghub.elsevier.com/retrieve/pii/S0006291X88803929; http://api.elsevier.com/content/article/PII:S0006291X88803929?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0006291X88803929?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0006291X88803929; http://dx.doi.org/10.1016/s0006-291x%2888%2980392-9; https://dx.doi.org/10.1016/s0006-291x%2888%2980392-9
Elsevier BV
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