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Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder

Biological Psychiatry, ISSN: 0006-3223, Vol: 45, Issue: 8, Page: 972-978
1999
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Article Description

Background: This study investigated the effects of catecholamine depletion with alpha-methylparatyrosine (AMPT) on mood indices in patients with bipolar disorder who were in long-term remission with lithium therapy. Methods: Eight subjects with DSM-IV bipolar disorder currently in remission for >3 months on lithium were included in the study. Subjects were given either AMPT or placebo, in a randomized double-blind manner, in two test sessions of 4 days each. Results: Subjects did not have any significant changes in mood during AMPT or placebo administration; however, 24–48 hours after the last active AMPT dose subjects had a transient relapse of hypomanic symptoms. Relapse of hypomanic symptoms did not correlate with increases in serum levels of homovanillic acid or 3-methoxy-4hydroxyphenylglycol. Conclusions: These findings suggest that the mechanism of prevention of manic relapse by long-term lithium therapy may be dependent on stability of the catecholamine system.

Bibliographic Details

http://www.sciencedirect.com/science/article/pii/S0006322398002935; http://dx.doi.org/10.1016/s0006-3223(98)00293-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033560984&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10386179; https://linkinghub.elsevier.com/retrieve/pii/S0006322398002935; http://linkinghub.elsevier.com/retrieve/pii/S0006322398002935; http://api.elsevier.com/content/article/PII:S0006322398002935?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0006322398002935?httpAccept=text/plain; http://dx.doi.org/10.1016/s0006-3223%2898%2900293-5; http://www.biologicalpsychiatryjournal.com/article/S0006-3223(98)00293-5/abstract; https://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=http%3A%2F%2Fwww.biologicalpsychiatryjournal.com%2Farticle%2FS0006-3223%2898%2900293-5%2Fabstract&rc=0&code=bps-site; http://acw.elsevier.com/SSOCore?return=https%3A%2F%2Fsecure.jbs.elsevierhealth.com%2Faction%2FconsumeSsoCookie%3FredirectUri%3Dhttp%253A%252F%252Fwww.biologicalpsychiatryjournal.com%252Faction%252FconsumeSharedSessionAction%253FJSESSIONID%253Daaa_7fsyCzQ04-ZPgjnxv%2526MAID%253DArEdGYcIXsdYInKv9%25252B9EHA%25253D%25253D%2526SERVER%253DWZ6myaEXBLF%25252FdY29RpN4fA%25253D%25253D%2526ORIGIN%253D723077385%2526RD%253DRD; http://acw.elsevier.com/SSOCore/?return=https%3A%2F%2Fsecure.jbs.elsevierhealth.com%2Faction%2FconsumeSsoCookie%3FredirectUri%3Dhttp%253A%252F%252Fwww.biologicalpsychiatryjournal.com%252Faction%252FconsumeSharedSessionAction%253FJSESSIONID%253Daaa_7fsyCzQ04-ZPgjnxv%2526MAID%253DArEdGYcIXsdYInKv9%25252B9EHA%25253D%25253D%2526SERVER%253DWZ6myaEXBLF%25252FdY29RpN4fA%25253D%25253D%2526ORIGIN%253D723077385%2526RD%253DRD; https://secure.jbs.elsevierhealth.com/action/consumeSsoCookie?redirectUri=http%3A%2F%2Fwww.biologicalpsychiatryjournal.com%2Faction%2FconsumeSharedSessionAction%3FJSESSIONID%3Daaa_7fsyCzQ04-ZPgjnxv%26MAID%3DArEdGYcIXsdYInKv9%252B9EHA%253D%253D%26SERVER%3DWZ6myaEXBLF%252FdY29RpN4fA%253D%253D%26ORIGIN%3D723077385%26RD%3DRD&acw=&utt=

Amit Anand; Scott W. Woods; Dennis S. Charney; Adam Darnell; Helen L. Miller; Angela Cappiello; Dan A. Oren; Robert M. Berman

Elsevier BV

Neuroscience

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