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Treatment of paragangliomas with radiation therapy

Otolaryngologic Clinics of North America, ISSN: 0030-6665, Vol: 34, Issue: 5, Page: 1007-1020
2001
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Article Description

Paragangliomas of the head and neck may be treated successfully with surgery, radiotherapy, or stereotactic radiosurgery, depending on the extent of the disease and the medical condition of the patient. The likelihood of cure is high, and there seems to be no significant difference between the treatment modalities in terms of tumor control. Surgery and radiotherapy have long track records; the data supporting stereotactic radiosurgery are limited, and the follow-up is short. Potential disadvantages of stereotactic radiosurgery are the possibility marginal miss of a tumor with a high likelihood of cure with moderate-dose fractionated radiotherapy and an increased risk of cranial neuropathy because of the large single dose of radiotherapy given with stereotactic radiosurgery. The authors treat patients with apparently completely resectable limited lesions, and in good medical condition, with surgery. Patients with more advanced tumors, those in poor medical condition, and those with tumors that recur after previous surgeries are treated with radiotherapy. The occasional patient with a limited tumor who is not a surgical candidate and cannot undergo a course of fractionated radiosurgery is considered for stereotactic radiosurgery.

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