Adjuvant action of Escherichia coli enterotoxin for delayed-type hypersensitivity to Oka vaccine virus on pernasal co-administration in mice
Vaccine, ISSN: 0264-410X, Vol: 19, Issue: 7, Page: 931-936
2000
- 6Citations
- 7Captures
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Metrics Details
- Citations6
- Citation Indexes6
- CrossRef5
- Captures7
- Readers7
Article Description
The usefulness of a mutant of Escherichia coli enterotoxin for the induction of cellular immunity to varicella-zoster virus as a mucosal adjuvant is assessed in mice. When a commercially available live varicella vaccine (the Oka strain) and toxin were once administered simultaneously via the nasal route, delayed-type hypersensitivity to Oka vaccine virus was significantly induced and detected by footpad test in mice. Moreover, when spleen cells from mice immunized with the vaccine and toxin were re-stimulated with live vaccine in vitro, they showed more thymidine uptake and produced more IL-2 than those from mice immunized with the vaccine alone. These results suggest that mutant enterotoxin has adjuvant action to induce a specific delayed-type hypersensitivity to Oka vaccine virus on nasal co-administration with live vaccine virus.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0264410X00002206; http://dx.doi.org/10.1016/s0264-410x(00)00220-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034703814&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11115718; http://linkinghub.elsevier.com/retrieve/pii/S0264410X00002206; http://api.elsevier.com/content/article/PII:S0264410X00002206?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0264410X00002206?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0264410X00002206; http://dx.doi.org/10.1016/s0264-410x%2800%2900220-6; https://dx.doi.org/10.1016/s0264-410x%2800%2900220-6
Elsevier BV
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