Production of IL-12 and IL-18 in human dendritic cells upon infection by Listeria monocytogenes
FEMS Immunology and Medical Microbiology, ISSN: 0928-8244, Vol: 35, Issue: 3, Page: 255-262
2003
- 30Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations30
- Citation Indexes30
- 30
- CrossRef27
- Captures23
- Readers23
- 23
Article Description
Dendritic cells (DCs) are major antigen-presenting cells of the immune system, which need to be activated in order to initiate an immune response. Here, we describe the immunostimulatory effects on human monocyte-derived DCs observed upon infection with Listeria monocytogenes or after treatment with listerial lipoteichoic acid (LTA) and lipopolysaccharide (LPS), respectively. All stimuli caused upregulation of costimulatory molecules, induced T-cell proliferative responses and secretion of cytokines in vitro. Infection of DCs with L. monocytogenes induced release of interleukin (IL)-12 and IL-18. In contrast treatment with purified listerial LTA yielded high levels of IL-18 release, but only minimal IL-12 production. Treatment of DCs with LPS conversely induced significant amounts of IL-12 production, but no IL-18. The release of both stimulating cytokines IL-12 and IL-18 upon infection with entire bacteria suggests that attenuated strains of L. monocytogenes may be a valuable tool for subunit vaccine delivery.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0928824402004704; http://dx.doi.org/10.1016/s0928-8244(02)00470-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=17344376824&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12648844; https://academic.oup.com/femspd/article-lookup/doi/10.1016/S0928-8244(02)00470-4; http://academic.oup.com/femspd/article-pdf/35/3/255/19166546/35-3-255.pdf; http://dx.doi.org/10.1016/s0928-8244%2802%2900470-4; https://dx.doi.org/10.1016/s0928-8244%2802%2900470-4; https://academic.oup.com/femspd/article/35/3/255/477608; https://academic.oup.com/femspd/article-pdf/35/3/255/19166546/35-3-255.pdf; http://femsim.oxfordjournals.org/cgi/doi/10.1016/S0928-8244(02)00470-4; https://academic.oup.com/femspd/article/35/3/255/477608/Production-of-IL12-and-IL18-in-human-dendritic
Oxford University Press (OUP)
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