Analogues of Human Parathyroid Hormone (1–31)NH 2 : Further Evaluation of the Effect of Conformational Constraint on Biological Activity
Bioorganic & Medicinal Chemistry, ISSN: 0968-0896, Vol: 10, Issue: 3, Page: 731-736
2002
- 4Citations
- 8Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
A series of conformationally-restricted analogues of hPTH was prepared, based on the parent peptide agonist, cyclo (Lys 18 -Asp 22 )[Ala 1,Nle 8,Lys 18,Asp 22,Leu 27 ]hPTH(1–31)NH 2 ( 2, EC 50 =0.29 nM). Truncation of 2 at either the N- or C-termini resulted in peptides with reduced agonist activity as measured by stimulation of adenylate cyclase activity in the rat osteosarcoma cell line (ROS 17/2.8). Alanine- and glycine-scanning at the N-terminus of 2 was consistent with data previously obtained on linear hPTH(1–34). Other locations within the primary sequence of hPTH(1–31)NH 2 were evaluated by the placement of the [ i, i +4] lactam constraining element. Ring size and lactam orientations at the 18–22 positions were also examined.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0968089601003352; http://dx.doi.org/10.1016/s0968-0896(01)00335-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036152605&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11814862; http://linkinghub.elsevier.com/retrieve/pii/S0968089601003352; http://api.elsevier.com/content/article/PII:S0968089601003352?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0968089601003352?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0968089601003352; http://dx.doi.org/10.1016/s0968-0896%2801%2900335-2; https://dx.doi.org/10.1016/s0968-0896%2801%2900335-2
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know