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The Effects of Mx 1 Locus on Immunity Tracts Components in Large White x Meishan F 2 Offspring

Agricultural Sciences in China, ISSN: 1671-2927, Vol: 6, Issue: 2, Page: 244-248
2007
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Article Description

The mouse Myxovirus resistance protein 1 (Mx1) is known to be sufficient to confer resistance to influenza viruses, and genes encoding Myxovirus resistance protein 1 (Mx1) is, therefore, an interesting candidate gene for disease resistance in farm animals. The porcine Mx 1 gene has already been identified and characterized based on its homology with mouse Mx 1; the full-length coding region of the pig Mx 1 gene spans 2 545 bp (M65087) and is organized into 17 exons compared with the human ortholog mRNA. In this study, the exons 9, 10, 11 and introns 6, 9 of the porcine Mx 1 gene were cloned and sequenced; two SNPs were identified in exons 9, 10, 11 but none of the SNPs led to an amino acid exchange, and the other eleven variants were detected in introns 6 and 9, respectively. Differences in allele frequency among Meishan, Large White, Tibetan, Tongcheng, Huainan, and Duroc pigs were observed within intron 9, of which an A → G substitution at position 186 was detected as an Msp I PCR-restriction fragment length polymorphism (PCR-RFLP). The association analysis using the Large WhitexMeishan F 2 offspring suggested that the Mx1 genotype was associated with variation in several immunity traits that are of interest in pig breeding. However, further investigations in more populations are needed to confirm the above concept.

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