Intrauterine factors and risk of breast cancer: a systematic review and meta-analysis of current evidence.

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The Lancet. Oncology, ISSN: 1474-5488, Vol: 8, Issue: 12, Page: 1088-1100

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10.1016/s1470-2045%2807%2970377-7, 10.1016/s1470-2045(07)70377-7
Xue, Fei, Michels, Karin B
Elsevier BV
review description
Emerging evidence suggests an association between female prenatal experience and her subsequent risk of developing breast cancer. Potential underlying mechanisms include variation in amounts of maternal endogenous sex hormones and growth hormones, germ-cell mutations, formation of cancer stem-cells, and other genetic or epigenetic events. We reviewed and summarised quantitatively the available data on intrauterine exposures and risk of breast cancer.

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Paternal age effect

The paternal age effect is the statistical relationship between paternal age at conception and biological effects on the child Such effects can relate to birthweight, congenital disorders, life expectancy, and psychological outcomes A 2017 review found that while severe health...

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