Lipoprotein-associated phospholipase A and risk of incident peripheral arterial disease: Findings from The Atherosclerosis Risk in Communities study (ARIC).

Citation data:

Atherosclerosis, ISSN: 1879-1484, Vol: 268, Page: 12-18

Publication Year:
2018
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PMID:
29169030
DOI:
10.1016/j.atherosclerosis.2017.11.007
Author(s):
Garg, Parveen K; Norby, Faye L; Polfus, Linda M; Boerwinkle, Eric; Gibbs, Richard A; Grove, Megan L; Folsom, Aaron R; Garimella, Pranav S; Matsushita, Kunihiro; Hoogeveen, Ron C; Ballantyne, Christie M Show More Hide
Publisher(s):
Elsevier BV
Tags:
Medicine
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article description
Results from prospective studies evaluating the relationship between elevated lipoprotein-associated phospholipase A (Lp-PLA) activity and incident peripheral arterial disease (PAD) have been mixed. We investigated whether higher Lp-PLA levels are associated with increased risk of incident PAD and whether PLA2G7 gene variants, which result in lower Lp-PLA levels, are associated with reduced risk of incident PAD.