Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism.

Citation data:

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, ISSN: 1678-4391, Vol: 22, Issue: 3, Page: 202-207

Publication Year:
2018
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PMID:
29787713
DOI:
10.1016/j.bjid.2018.04.004
Author(s):
Carneiro, Valdirene Leão; Bendicho, Maria Teresita; Santos, Rosalina Guedes; Casela, Marilda; Netto, Eduardo M; Mota, Scarlet Torres Moraes; Pina, Iza Cristina Araújo; Nascimento, Roberto Meyer; Freire, Songeli Menezes; Barbosa, Theolis
Publisher(s):
Elsevier BV
Tags:
Medicine
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article description
Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance.