17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle.

Citation data:

Cell metabolism, ISSN: 1932-7420, Vol: 27, Issue: 1, Page: 167-179.e7

Publication Year:
2018
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PMID:
29103922
DOI:
10.1016/j.cmet.2017.10.003
Author(s):
Torres, Maria J; Kew, Kim A; Ryan, Terence E; Pennington, Edward Ross; Lin, Chien-Te; Buddo, Katherine A; Fix, Amy M; Smith, Cheryl A; Gilliam, Laura A; Karvinen, Sira; Lowe, Dawn A; Spangenburg, Espen E; Zeczycki, Tonya N; Shaikh, Saame Raza; Neufer, P Darrell Show More Hide
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology
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article description
Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not well understood. In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle. E2 was detected by liquid chromatography-mass spectrometry in mitochondrial membranes and varied according to whole-body E2 status independently of ERα. Loss of E2 increased mitochondrial membrane microviscosity and HO emitting potential, whereas E2 administration in vivo and in vitro restored membrane E2 content, microviscosity, complex I and I + III activities, HO emitting potential, and submaximal OXPHOS responsiveness. These findings demonstrate that E2 directly modulates membrane biophysical properties and bioenergetic function in mitochondria, offering a direct mechanism by which E2 status broadly influences energy homeostasis.