Barbara Wallner; Claus Vogl; Doris Rigler; Elif Bozlak; Thomas Druml; Gottfried Brem; Nicola Palmieri; Christian Schlötterer; Vidhya Jagannathan; Tosso Leeb; Ruedi Fries; Jens Tetens; Georg Thaller; Julia Metzger; Ottmar Distl; Gabriella Lindgren; Leif Andersson; Carl Johan Rubin; Robert Schaefer; Molly McCue; Markus Neuditschko; Stefan Rieder Show More Hide
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences
article description
The Y chromosome directly reflects male genealogies, but the extremely low Y chromosome sequence diversity in horses has prevented the reconstruction of stallion genealogies [1, 2]. Here, we resolve the first Y chromosome genealogy of modern horses by screening 1.46 Mb of the male-specific region of the Y chromosome (MSY) in 52 horses from 21 breeds. Based on highly accurate pedigree data, we estimated the de novo mutation rate of the horse MSY and showed that various modern horse Y chromosome lineages split much later than the domestication of the species. Apart from few private northern European haplotypes, all modern horse breeds clustered together in a roughly 700-year-old haplogroup that was transmitted to Europe by the import of Oriental stallions. The Oriental horse group consisted of two major subclades: the Original Arabian lineage and the Turkoman horse lineage. We show that the English Thoroughbred MSY was derived from the Turkoman lineage and that English Thoroughbred sires are largely responsible for the predominance of this haplotype in modern horses.