Prognostic significance of receptor for hyaluronan acid-mediated motility (CD168) in acute pediatric leukemias - assessment of clinical outcome, post induction, end of treatment and minimal residual disease.

Citation data:

Hematology, transfusion and cell therapy, ISSN: 2531-1387, Vol: 40, Issue: 4, Page: 310-316

Publication Year:
2018
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PMID:
30370408
DOI:
10.1016/j.htct.2018.01.008
Author(s):
Shalini, Chinnathambi Narayanan Sai; Suman, Febe Renjitha; Jacob, Jerusha Samuela; Rajendran, Rithika; Scott, Julius Xavier; Latha, Magadha Sneha
Publisher(s):
Elsevier BV; Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH)
Tags:
Medicine
article description
The extracellular matrix protein hyaluronan acid plays an active in role in tumor cell proliferation and invasion. Hyaluronan acid receptors, namely CD168 or the receptor for hyaluronan acid-mediated motility (RHAMM) and CD44 have been implicated in promoting malignancy. There is a lacuna in data on the expression of the receptor in pediatric leukemias.