Mutations in the breakpoint cluster region-Abelson murine leukemia 1 gene in Brazilian patients with chronic myeloid leukemia.

Citation data:

Hematology, transfusion and cell therapy, ISSN: 2531-1387, Vol: 40, Issue: 4, Page: 363-367

Publication Year:
2018

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PMID:
30370415
DOI:
10.1016/j.htct.2018.03.005
Author(s):
Costa, Heloísa Zorzi; Pereira, Noemi Farah; Kaminski, Luciane; Pasquini, Ricardo; Funke, Vaneuza Araujo Moreira; Mion, Ana Lucia Vieira
Publisher(s):
Elsevier BV; Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH)
Tags:
Medicine
article description
Mutations in the gene are the leading cause of resistance to treatment with tyrosine kinase inhibitors in chronic myeloid leukemia patients. Mutations have been detected throughout the extension of the kinase domain of this gene and it is important to investigate their positions because there may be a difference in clinical relevance.