ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study.

Citation data:

Hematology, transfusion and cell therapy, ISSN: 2531-1387, Vol: 40, Issue: 4, Page: 317-325

Publication Year:
2018
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PMID:
30370409
DOI:
10.1016/j.htct.2018.03.008
Author(s):
Correia, Rodolfo Patussi; Matos E Silva, Flávia Amoroso; Bacal, Nydia Strachman; Campregher, Paulo Vidal; Hamerschlak, Nelson; Amarante-Mendes, Gustavo Pessini
Publisher(s):
Elsevier BV; Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH)
Tags:
Medicine
article description
Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells, participating in their expansion, differentiation and survival. Chronic lymphocytic leukemia B cells may also drive functional and phenotypic changes of non-malignant T cells. There are few data about the association between memory T cells and prognosis, especially related to ZAP-70, a common reliable surrogate of the gold standard chronic lymphocytic leukemia prognostic markers.