A subpopulation of activated retinal macrophages selectively migrated to regions of cone photoreceptor stress, but had limited effect on cone death in a mouse model for type 2 Leber congenital amaurosis.

Citation data:

Molecular and cellular neurosciences, ISSN: 1095-9327, Vol: 85, Page: 70-81

Publication Year:
2017
Usage 1
Abstract Views 1
Social Media 63
Shares, Likes & Comments 61
Tweets 2
PMID:
28889993
DOI:
10.1016/j.mcn.2017.09.002
Author(s):
Tang, Peter H, Pierson, Mark J, Heuss, Neal D, Gregerson, Dale S
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology, Neuroscience
Most Recent Tweet View All Tweets
article description
Studies of antigen presentation in retina using mice that expressed green fluorescent protein (GFP) from a transgenic CD11c promoter found that retinal GFP cells possessed antigen presentation function. Subsequent studies found that these high GFP cells preferentially localized to sites of retinal injury, consistent with their APC function. Interest in the roles of macrophages in degenerative CNS diseases led us to study the GFP cells in a retinal model of neurodegeneration. We asked if apoptotic cone photoreceptor cell death in Rpe65 knockout mice induced the GFP cells, explored their relationship to resident microglia (MG), and tested their role in cone survival.

This article has 0 Wikipedia mention.