A subpopulation of activated retinal macrophages selectively migrated to regions of cone photoreceptor stress, but had limited effect on cone death in a mouse model for type 2 Leber congenital amaurosis.

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Molecular and cellular neurosciences, ISSN: 1095-9327, Vol: 85, Page: 70-81

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Tang, Peter H, Pierson, Mark J, Heuss, Neal D, Gregerson, Dale S
Elsevier BV
Biochemistry, Genetics and Molecular Biology, Neuroscience
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Studies of antigen presentation in retina using mice that expressed green fluorescent protein (GFP) from a transgenic CD11c promoter found that retinal GFP cells possessed antigen presentation function. Subsequent studies found that these high GFP cells preferentially localized to sites of retinal injury, consistent with their APC function. Interest in the roles of macrophages in degenerative CNS diseases led us to study the GFP cells in a retinal model of neurodegeneration. We asked if apoptotic cone photoreceptor cell death in Rpe65 knockout mice induced the GFP cells, explored their relationship to resident microglia (MG), and tested their role in cone survival.

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