Neural and neuroendocrine predictors of pharmacological treatment response in adolescents with depression: A preliminary study.

Citation data:

Progress in neuro-psychopharmacology & biological psychiatry, ISSN: 1878-4216, Vol: 81, Page: 194-202

Publication Year:
2018
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PMID:
29100972
DOI:
10.1016/j.pnpbp.2017.10.015
Author(s):
Klimes-Dougan, Bonnie; Westlund Schreiner, Melinda; Thai, Michelle; Gunlicks-Stoessel, Meredith; Reigstad, Kristina; Cullen, Kathryn R
Publisher(s):
Elsevier BV
Tags:
Pharmacology, Toxicology and Pharmaceutics; Neuroscience
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article description
Typically, about 30 to 50% of adolescents with depression fail to respond to evidence-based treatments, including antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs). Efforts for identifying predictors and moderators of treatment response are needed to begin to address critical questions relevant to personalized care in adolescent depression. In this pilot study, we aim to identify biological predictors of response to antidepressant treatment.