Correlation between urinary GAG and anti-idursulfase ERT neutralizing antibodies during treatment with NICIT immune tolerance regimen: A case report.

Citation data:

Molecular genetics and metabolism, ISSN: 1096-7206, Vol: 122, Issue: 1-2, Page: 92-99

Publication Year:
2017
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PMID:
28610913
DOI:
10.1016/j.ymgme.2017.06.001
Author(s):
Kim, Sarah, Whitley, Chester B, Jarnes Utz, Jeanine R
Publisher(s):
Elsevier BV
Tags:
Medicine, Biochemistry, Genetics and Molecular Biology
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article description
Antibodies to intravenous idursulfase enzyme replacement therapy (ERT) for patients with Hunter syndrome (mucopolysaccharidosis type II, MPS II) can have a harmful clinical impact, including both increasing risk of infusion reactions and inhibiting therapeutic activity. Thus, failure to monitor anti-idursulfase antibodies and neutralizing antibodies, and delays in reporting results, may postpone critical clinical decisions.

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