Flavanone plasma pharmacokinetics from blood orange juice in human subjects
British Journal of Nutrition, ISSN: 0007-1145, Vol: 98, Issue: 1, Page: 165-172
2007
- 57Citations
- 48Captures
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Metrics Details
- Citations57
- Citation Indexes56
- 56
- CrossRef55
- Policy Citations1
- Policy Citation1
- Captures48
- Readers48
- 48
Article Description
Some blood orange juice (BOJ) flavanones may have antioxidant, anti-inflammatory, anti-allergic, hypolipidaemic, vasoprotective and anticarcinogenic properties. The aim of the present study was to evaluate the pharmacokinetics of hesperetin and naringenin in human subjects after BOJ intake. In a cross-over study, seven healthy female volunteers consumed 150 and 300 ml BOJ corresponding to about 51-102 mg hesperetin and to 6-12 mg naringenin, respectively. Plasma samples were collected before, each hour for 8 h and 24 h after BOJ administration and analysed for their content of hesperetin and naringenin by liquid chromatography-MS/MS. The plasma concentrations of these compounds were dose dependent and the peak concentration (C) was reached in 5.1 (sd 0.6) h after BOJ intake. The C of hesperetin was 43.4 (sd 32.4) and 79.8 (sd 60.1) ng/ml after 150 and 300 ml intake, respectively. For naringenin the plasma peak was 16.4 (sd 11.9) and 34.0 (sd 20.6) ng/ml. Moreover, the conjugated forms of these flavanones represent more than 95 % of the plasma concentration. The results indicate that both hesperetin and naringenin are bioavailable after BOJ intake; naringenin seemingly more so than hesperetin. © The Authors 2007.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34547982286&origin=inward; http://dx.doi.org/10.1017/s0007114507699358; http://www.ncbi.nlm.nih.gov/pubmed/17367568; http://www.journals.cambridge.org/abstract_S0007114507699358; https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114507699358; https://www.cambridge.org/core/product/identifier/S0007114507699358/type/journal_article
Cambridge University Press (CUP)
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