Asymmetric Synthesis of cis-3,4-Dihydrocoumarins via [4 + 2] Cycloadditions Catalyzed by Amidine Derivatives.

Citation data:

The Journal of organic chemistry, ISSN: 1520-6904, Vol: 82, Issue: 10, Page: 5424-5432

Publication Year:
2017
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PMID:
28441490
DOI:
10.1021/acs.joc.7b00367
Author(s):
Jin, Jing-Hai; Li, Xiang-Yu; Luo, Xiaoyan; Fossey, John S; Deng, Wei-Ping
Publisher(s):
American Chemical Society (ACS)
Tags:
Chemistry
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article description
A highly efficient chiral amidine derivative-catalyzed tandem Michael addition/lactonization of carboxylic acids and o-quinone methides (o-QMs) has been developed that enables the asymmetric synthesis of cis-3,4-dihydrocoumarins bearing contiguous tertiary stereogenic centers in high yields with excellent stereoselectivities.