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Fast heck-cassar-sonogashira (hcs) reactions in green solvents

Organic Letters, ISSN: 1523-7052, Vol: 22, Issue: 10, Page: 3969-3973
2020
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Article Description

The replacement of toxic solvents with greener alternatives in Heck-Cassar-Sonogashira (HCS) cross-couplings was investigated. The fine-tuning of the HCS protocol allowed to achieve complete conversions and high speed under mild conditions. N-Hydroxyethylpyrrolidone (HEP) gave the best results. Moreover, the methodology was successfully applied to the synthesis of an intermediate of the anticancer drug Erlotinib, demonstrating the versatility of the new green protocol.

Bibliographic Details

L. Ferrazzano; G. Martelli; T. Fantoni; A. Daka; D. Corbisiero; W. Cabri; A. Tolomelli; A. Viola; A. Ricci

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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