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Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

Organic Letters, ISSN: 1523-7052, Vol: 17, Issue: 20, Page: 4980-4983
2015
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Article Description

The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings.

Bibliographic Details

Liao, George P; Abdelraheem, Eman M M; Neochoritis, Constantinos G; Kurpiewska, Katarzyna; Kalinowska-Tłuścik, Justyna; McGowan, David C; Dömling, Alexander

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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