PlumX Metrics
Embed PlumX Metrics

Solid-state hydration/dehydration of erythromycin a investigated by ab initio powder X-ray diffraction analysis: Stoichiometric and nonstoichiometric dehydrated hydrate

Crystal Growth and Design, ISSN: 1528-7483, Vol: 13, Issue: 5, Page: 2060-2066
2013
  • 51
    Citations
  • 0
    Usage
  • 45
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    51
    • Citation Indexes
      51
  • Captures
    45

Article Description

The stable dihydrate crystalline phase (DH) of erythromycin A loses water upon heating to give the anhydrous phase I (AI). Further heating then results in a polymorphic transformation via the amorphous state (melt) to give another anhydrous phase II (AII). The anhydrous phases of AI and AII undergo hydration when increasing the humidity. The crystals of AI showed stoichiometric hydration to give DH, whereas the crystals of AII showed nonstoichiometric hydration to give the humidity dependent nonstoichiometric hydrate phase (NSH). The crystal structures of AI and AII were directly determined from powder X-ray diffraction data using the direct space strategy for the structure solution followed by Rietveld refinement. From the structural properties of AI and AII, aspects of the mechanism of the solid-state transformations of DH and the hydration behavior of AI and AII have been determined, and the importance of the hydrophilicity of the voids has been revealed. © 2013 American Chemical Society.

Bibliographic Details

Kotaro Fujii; Masahide Aoki; Hidehiro Uekusa

American Chemical Society (ACS)

Chemistry; Materials Science; Physics and Astronomy

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know