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Protein and enzyme gated supramolecular disassembly

Journal of the American Chemical Society, ISSN: 0002-7863, Vol: 136, Issue: 6, Page: 2220-2223
2014
  • 77
    Citations
  • 0
    Usage
  • 66
    Captures
  • 0
    Mentions
  • 18
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    77
  • Captures
    66
  • Social Media
    18
    • Shares, Likes & Comments
      18
      • Facebook
        18

Article Description

An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications. © 2014 American Chemical Society.

Bibliographic Details

Guo, Jing; Zhuang, Jiaming; Wang, Feng; Raghupathi, Krishna R; Thayumanavan, S

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology

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