PlumX Metrics
Embed PlumX Metrics

Pd-catalyzed intramolecular C-N bond cleavage, 1,4-migration, spC-H activation, and Heck reaction: Four controllable diverse pathways depending on the judicious choice of the base and ligand

Journal of the American Chemical Society, ISSN: 1520-5126, Vol: 137, Issue: 3, Page: 1341-1347
2015
  • 143
    Citations
  • 0
    Usage
  • 60
    Captures
  • 0
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    143
  • Captures
    60
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Article Description

Diverse and controllable pathways induced by palladium-catalyzed intramolecular Heck reaction of N-vinylacetamides for the synthesis of nitrogen-containing products in reasonable to high yields via tuning the phosphine ligands and bases are reported. Domino reactions including unique β-N - Pd elimination, 1,4-Pd migration, or direct acyl C - H bond functionalization were found to be involved forming different products, respectively. Given the ability of using the same starting material to generate diverse products via completely different chemoselective processes, these current methodologies offer straightforward access to valuable nitrogencontaining products under mild reaction conditions as well as inspire the discovery of novel reactions. (Chemical Equation Presented).

Bibliographic Details

Wang, Min; Zhang, Xiang; Zhuang, Yu-Xuan; Xu, Yun-He; Loh, Teck-Peng

American Chemical Society (ACS)

Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know