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Molecular modeling, synthesis, and preliminary biological evaluation of glutathione-S-transferase inhibitors as potential therapeutic agents

Journal of Medicinal Chemistry, ISSN: 0022-2623, Vol: 48, Issue: 19, Page: 6084-6089
2005
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Article Description

Changes in the GSH/GST system have been found to correlate with resistance to anticancer alkylating agents, presumably through accelerated detoxification of these drugs since some GSTs have been shown to catalyze the conjugation of GSH to specific antineoplastic agents. GSH-alkyl derivatives were designed by molecular modeling, synthesized, and tested as inhibitors of human GST-Pi. © 2005 American Chemical Society.

Bibliographic Details

Procopio, Antonio; Alcaro, Stefano; Cundari, Sante; De Nino, Antonio; Ortuso, Francesco; Sacchetta, Paolo; Pennelli, Alfonso; Sindona, Giovanni

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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