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Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase

Journal of Natural Products, ISSN: 0163-3864, Vol: 70, Issue: 9, Page: 1458-1461
2007
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Article Description

Five new benzylphenethylamine alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasine, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the new alkaloids were established by means of extensive spectroscopic methods, and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC = 1.80 μM), a known alkaloid, showed strong activity against tobacco mosaic virus by the half-leaf method. Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase. 8-Demethoxy-10-O-methylhostasine was found to possess significant activity, with an IC of 2.32 μM. © 2007 American Chemical Society and American Society of Pharmacognosy.

Bibliographic Details

Wang, Yue-Hu; Zhang, Zhong-Kai; Yang, Fu-Mei; Sun, Qian-Yun; He, Hong-Ping; Di, Ying-Tong; Mu, Shu-Zhen; Lu, Yang; Chang, Ying; Zheng, Qi-Tai; Ding, Ming; Dong, Jia-Hong; Hao, Xiao-Jiang

American Chemical Society (ACS)

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Medicine

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