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Unprecedented occurrence of isoaspartic acid in a plant cyclopeptide

Organic Letters, ISSN: 1523-7060, Vol: 14, Issue: 2, Page: 576-579
2012
  • 8
    Citations
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  • 16
    Captures
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Metrics Details

  • Citations
    8
    • Citation Indexes
      8
  • Captures
    16

Article Description

Three structurally related cycloheptapeptides, cyclocitropsides A-C, have been isolated from a MeOH extract of the root bark of Citropsis articulata, a medicinal plant in Uganda. Their sequences were elucidated on the basis of their MS/MS fragmentation, extensive 2D-NMR, chemical degradation, and biochemical modifications. Surprisingly, the sequence of cyclocitropside C differed from that of cyclocitropside B only by an Asp /isoAsp substitution. This is the first report of an isoAsp residue in a plant cyclic peptide. © 2012 American Chemical Society.

Bibliographic Details

Lacroix, Damien; Prado, Soizic; Kamoga, Dennis; Kasenene, John; Zirah, Séverine; Bodo, Bernard

American Chemical Society (ACS)

Biochemistry, Genetics and Molecular Biology; Chemistry

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