The Essential Medicinal Chemistry of Curcumin.

Citation data:

Journal of medicinal chemistry, ISSN: 1520-4804, Vol: 60, Issue: 5, Page: 1620-1637

Publication Year:
2017
Usage 252
Clicks 186
Abstract Views 41
Link-outs 25
Captures 290
Readers 289
Exports-Saves 1
Mentions 68
News Mentions 28
Comments 21
Blog Mentions 17
References 2
Social Media 642
Tweets 460
Shares, Likes & Comments 182
Citations 62
Citation Indexes 62
Ratings
Reddit 33
PMID:
28074653
DOI:
10.1021/acs.jmedchem.6b00975
Author(s):
Nelson, Kathryn M; Dahlin, Jayme L; Bisson, Jonathan; Graham, James; Pauli, Guido F; Walters, Michael A
Publisher(s):
American Chemical Society (ACS)
Tags:
Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
Most Recent Tweet View All Tweets
Most Recent Blog Mention
Most Recent News Mention
review description
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.