The Essential Medicinal Chemistry of Curcumin.

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Journal of medicinal chemistry, ISSN: 1520-4804, Vol: 60, Issue: 5, Page: 1620-1637

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Nelson, Kathryn M, Dahlin, Jayme L, Bisson, Jonathan, Graham, James, Pauli, Guido F, Walters, Michael A
American Chemical Society (ACS)
Biochemistry, Genetics and Molecular Biology, Pharmacology, Toxicology and Pharmaceutics
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review description
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.

This review has 2 Wikipedia mentions.


Curcumin is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring Chemically, curc...

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Turmeric (Curcuma longa) cite web is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae It is native to Southeast Asia, and requires temperatures between and a considerable amount of annual rainfall to thrive. Plants are gathered annually for their rh...

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