Genetic Design via Combinatorial Constraint Specification.

Citation data:

ACS synthetic biology, ISSN: 2161-5063, Vol: 6, Issue: 11, Page: 2130-2135

Publication Year:
2017
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PMID:
28874044
DOI:
10.1021/acssynbio.7b00154
Author(s):
Bhatia, Swapnil P, Smanski, Michael J, Voigt, Christopher A, Densmore, Douglas M
Publisher(s):
American Chemical Society (ACS)
Tags:
Engineering, Biochemistry, Genetics and Molecular Biology
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article description
We present a formal language for specifying via constraints a "design space" of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spaces, and possesses algorithms for common operations on design spaces. The flexibility of this approach is demonstrated using a 16-gene nitrogen fixation pathway and genetic logic circuits.

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