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Nonmutagenic carcinogens induce intrachromosomal recombination in yeast

Nature, ISSN: 0028-0836, Vol: 337, Issue: 6204, Page: 285-288
1989
  • 141
    Citations
  • 0
    Usage
  • 12
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    141
    • Citation Indexes
      133
    • Policy Citations
      7
      • Policy Citation
        7
    • Patent Family Citations
      1
      • Patent Families
        1
  • Captures
    12

Article Description

To identify environmental carcinogens there is a need for inexpensive and reliable short-term tests, but certain human or animal carcinogens are persistently undetectable as mutagents with the Antes assay or with other short-term tests currently in use. Thus there is a need for short-term tests which detect carcinogens missed by the Ames assay. Because of the association of carcino-genesis with genome rearrangement, a system screening for intrachromosomal recombination resulting in genome rearrangement has been constructed in Saccharomyces ceremstae. Evaluation of this system shows indncibility by a variety of carcinogens not detectable by the Ames assay or various other short-term tests. In the light of these results it is tempting to speculate that 'nongenotoxic carcinogens' are in fact genotoxic but, in the past, the tools to measure the genetic alterations they induce have been inappropriate. © 1989 Nature Publishing Group.

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