Nonmutagenic carcinogens induce intrachromosomal recombination in yeast
Nature, ISSN: 0028-0836, Vol: 337, Issue: 6204, Page: 285-288
1989
- 141Citations
- 12Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations141
- Citation Indexes133
- 133
- CrossRef110
- Policy Citations7
- Policy Citation7
- Patent Family Citations1
- Patent Families1
- Captures12
- Readers12
- 12
Article Description
To identify environmental carcinogens there is a need for inexpensive and reliable short-term tests, but certain human or animal carcinogens are persistently undetectable as mutagents with the Antes assay or with other short-term tests currently in use. Thus there is a need for short-term tests which detect carcinogens missed by the Ames assay. Because of the association of carcino-genesis with genome rearrangement, a system screening for intrachromosomal recombination resulting in genome rearrangement has been constructed in Saccharomyces ceremstae. Evaluation of this system shows indncibility by a variety of carcinogens not detectable by the Ames assay or various other short-term tests. In the light of these results it is tempting to speculate that 'nongenotoxic carcinogens' are in fact genotoxic but, in the past, the tools to measure the genetic alterations they induce have been inappropriate. © 1989 Nature Publishing Group.
Bibliographic Details
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know