Calcium channel gating and modulation by transmitters depend on cellular compartmentalization
Nature Neuroscience, ISSN: 1097-6256, Vol: 3, Issue: 7, Page: 670-678
2000
- 53Citations
- 54Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations53
- Citation Indexes53
- 53
- CrossRef40
- Captures54
- Readers54
- 54
Article Description
Voltage-gated Ca channels participate in dendritic integration, yet functional properties of Ca channels and mechanisms of their modulation by neurotransmitters in dendrites are unknown. Here we report how pharmacologically identified Ca channels behave in different neural compartments. Whole-cell and cell-attached patch-clamp recordings were made on both cell bodies and electrically isolated dendrites of sympathetic neurons. We found not only that Ca channel populations differentially contribute to somatic and dendritic currents but also that families of Ca channels display gating properties and neurotransmitter modulation that depend on channel compartmentalization. By comparison with their somatic counterparts, dendritic N-type Ca currents were hypersensitive to neurotransmitters and G proteins. Single-channel analysis showed that dendrites express a unique N-type channel that has enhanced interaction with Gβγ. Thus Ca channels in dendrites seem to be specialized elements with unique regulatory mechanisms.
Bibliographic Details
Springer Science and Business Media LLC
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