PlumX Metrics
Embed PlumX Metrics

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Nature, ISSN: 0028-0836, Vol: 461, Issue: 7268, Page: 1282-1286
2009
  • 2,579
    Citations
  • 0
    Usage
  • 2,162
    Captures
  • 10
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2,579
    • Citation Indexes
      2,572
    • Patent Family Citations
      7
      • Patent Families
        7
  • Captures
    2,162
  • Mentions
    10
    • News Mentions
      7
      • News
        7
    • References
      2
      • Wikipedia
        2
    • Blog Mentions
      1
      • Blog
        1

Most Recent News

Causal Effects of Gut Microbiota and Metabolites on Chronic Obstructive Pulmonary Disease: A Bidirectional Two Sample Mendelian Randomization Study

Introduction Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disorder characterized by chronic respiratory symptoms such as dyspnea, cough, sputum production, and/or exacerbations. These

Article Description

The immune system responds to pathogens by a variety of pattern recognition molecules such as the Toll-like receptors (TLRs), which promote recognition of dangerous foreign pathogens. However, recent evidence indicates that normal intestinal microbiota might also positively influence immune responses, and protect against the development of inflammatory diseases. One of these elements may be short-chain fatty acids (SCFAs), which are produced by fermentation of dietary fibre by intestinal microbiota. A feature of human ulcerative colitis and other colitic diseases is a change in healthy microbiota such as Bifidobacterium and Bacteriodes, and a concurrent reduction in SCFAs. Moreover, increased intake of fermentable dietary fibre, or SCFAs, seems to be clinically beneficial in the treatment of colitis. SCFAs bind the G-protein-coupled receptor 43 (GPR43, also known as FFAR2), and here we show that SCFA-GPR43 interactions profoundly affect inflammatory responses. Stimulation of GPR43 by SCFAs was necessary for the normal resolution of certain inflammatory responses, because GPR43-deficient (Gpr43-/-) mice showed exacerbated or unresolving inflammation in models of colitis, arthritis and asthma. This seemed to relate to increased production of inflammatory mediators by Gpr43-/-immune cells, and increased immune cell recruitment. Germ-free mice, which are devoid of bacteria and express little or no SCFAs, showed a similar dysregulation of certain inflammatory responses. GPR43 binding of SCFAs potentially provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses. © 2009 Macmillan Publishers Limited. All rights reserved.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know