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Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera

Nature Communications, ISSN: 2041-1723, Vol: 6, Issue: 1, Page: 8322
2015
  • 450
    Citations
  • 0
    Usage
  • 621
    Captures
  • 3
    Mentions
  • 236
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    450
    • Citation Indexes
      446
    • Patent Family Citations
      2
      • Patent Families
        2
    • Policy Citations
      2
      • Policy Citation
        2
  • Captures
    621
  • Mentions
    3
    • News Mentions
      2
      • News
        2
    • References
      1
      • Wikipedia
        1
  • Social Media
    236
    • Shares, Likes & Comments
      236
      • Facebook
        236

Most Recent News

Comparative Genomic and Functional Characterization of Lactobacillus casei Group (LCG) Probiotic Strains Isolated from Traditional Yogurts by Next-Generation Sequencing

Key words Lactobacillus, Lactobacillus casei, Lactobacillus casei group (LCG), Next-generation sequencing (NGS), Yogurt INTRODUCTION Lactobacillus is the largest genus of family Lactobacillaceae currently containing more

Article Description

Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.

Bibliographic Details

Sun, Zhihong; Harris, Hugh M. B.; McCann, Angela; Guo, Chenyi; Argimón, Silvia; Zhang, Wenyi; Yang, Xianwei; Jeffery, Ian B; Cooney, Jakki C.; Kagawa, Todd F.; Liu, Wenjun; Song, Yuqin; Salvetti, Elisa; Wrobel, Agnieszka; Rasinkangas, Pia; Parkhill, Julian; Rea, Mary C.; O’Sullivan, Orla; Ritari, Jarmo; Douillard, François P.; Paul Ross, R.; Yang, Ruifu; Briner, Alexandra E.; Felis, Giovanna E.; de Vos, Willem M.; Barrangou, Rodolphe; Klaenhammer, Todd R.; Caufield, Page W.; Cui, Yujun; Zhang, Heping; O’Toole, Paul W.

Springer Science and Business Media LLC

Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy

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