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Programs for the persistence, vigilance and control of human CD8 + lung-resident memory T cells

Nature Immunology, ISSN: 1529-2916, Vol: 17, Issue: 12, Page: 1467-1478
2016
  • 365
    Citations
  • 0
    Usage
  • 342
    Captures
  • 0
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    365
  • Captures
    342
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Article Description

Tissue-resident memory T cells (T RM cells) in the airways mediate protection against respiratory infection. We characterized T RM cells expressing integrin α E (CD103) that reside within the epithelial barrier of human lungs. These cells had specialized profiles of chemokine receptors and adhesion molecules, consistent with their unique localization. Lung T RM cells were poised for rapid responsiveness by constitutive expression of deployment-ready mRNA encoding effector molecules, but they also expressed many inhibitory regulators, suggestive of programmed restraint. A distinct set of transcription factors was active in CD103 + T RM cells, including Notch. Genetic and pharmacological experiments with mice revealed that Notch activity was required for the maintenance of CD103 + T RM cells. We have thus identified specialized programs underlying the residence, persistence, vigilance and tight control of human lung T RM cells.

Bibliographic Details

Hombrink, Pleun; Helbig, Christina; Backer, Ronald A; Piet, Berber; Oja, Anna E; Stark, Regina; Brasser, Giso; Jongejan, Aldo; Jonkers, René E; Nota, Benjamin; Basak, Onur; Clevers, Hans C; Moerland, Perry D; Amsen, Derk; van Lier, René A W

Springer Science and Business Media LLC

Medicine; Immunology and Microbiology

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