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Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Nature Medicine, ISSN: 1078-8956, Vol: 11, Issue: 1, Page: 32-34
2005
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Des humains avec des organes de porc ? L'étude française qui renforce les espoirs de greffes

Des êtres humains vont-ils pouvoir, un jour, vivre avec des organes de porcs ? L’hypothèse relevait encore de la science-fiction il y a quelques années. Mais les progrès fulgurants en xénotransplantation - les greffes d’organes d’animaux sur des êtres humains - pourraient changer la donne. De quoi donner de l’espoir aux nombreux patients qui souffrent de la pénurie d’organe, un problème de santé p

Article Description

The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using α-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.

Bibliographic Details

Yamada, Kazuhiko; Yazawa, Koji; Shimizu, Akira; Iwanaga, Takehiro; Hisashi, Yosuke; Nuhn, Matthew; O'Malley, Patricia; Nobori, Shuji; Vagefi, Parsia A; Patience, Clive; Fishman, Jay; Cooper, David K C; Hawley, Robert J; Greenstein, Julia; Schuurman, Henk-Jan; Awwad, Michel; Sykes, Megan; Sachs, David H

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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