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Similar network activity from disparate circuit parameters

Nature Neuroscience, ISSN: 1097-6256, Vol: 7, Issue: 12, Page: 1345-1352
2004
  • 781
    Citations
  • 0
    Usage
  • 850
    Captures
  • 3
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    781
  • Captures
    850
  • Mentions
    3
    • References
      2
      • Wikipedia
        2
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Article Description

It is often assumed that cellular and synaptic properties need to be regulated to specific values to allow a neuronal network to function properly. To determine how tightly neuronal properties and synaptic strengths need to be tuned to produce a given network output, we simulated more than 20 million versions of a three-cell model of the pyloric network of the crustacean stomatogastric ganglion using different combinations of synapse strengths and neuron properties. We found that virtually indistinguishable network activity can arise from widely disparate sets of underlying mechanisms, suggesting that there could be considerable animal-to-animal variability in many of the parameters that control network activity, and that many different combinations of synaptic strengths and intrinsic membrane properties can be consistent with appropriate network performance.

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