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Umbilical-cord blood transplantation for the treatment of cancer

Nature Reviews Cancer, ISSN: 1474-175X, Vol: 3, Issue: 7, Page: 526-532
2003
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Review Description

Haematopoietic stem-cell transplantation is used to treat many haematological cancers, but is limited by the lack of suitable bone-marrow donors, the risk of graft-versus-host disease (GVHD) and slow immune reconstitution. Umbilical-cord blood is an alternative source of haematopoietic stem cells that has recently been tested in both child and adult cancer patients. These studies have identified several advantages to umbilical-cord cell transplantation, including a lower incidence of GVHD. Umbilical-cord blood is therefore a promising alternative to bone-marrow-derived stem cells.

Bibliographic Details

Juliet N. Barker; John E. Wagner

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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