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Forkhead box proteins: Tuning forks for transcriptional harmony

Nature Reviews Cancer, ISSN: 1474-175X, Vol: 13, Issue: 7, Page: 482-495
2013
  • 565
    Citations
  • 0
    Usage
  • 490
    Captures
  • 0
    Mentions
  • 2
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    565
  • Captures
    490
  • Social Media
    2
    • Shares, Likes & Comments
      2
      • Facebook
        2

Review Description

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers. © 2013 Macmillan Publishers Limited.

Bibliographic Details

Lam, Eric W.-F.; Brosens, Jan J.; Gomes, Ana R.; Koo, Chuay-Yeng

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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