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FANCD2 limits replication stress and genome instability in cells lacking BRCA2

Nature Structural and Molecular Biology, ISSN: 1545-9985, Vol: 23, Issue: 8, Page: 755-757
2016
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Article Description

The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication-fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication-fork progression and genomic instability. Our results identify a new role of FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, thereby affecting cell survival and treatment responses.

Bibliographic Details

Michl, Johanna; Zimmer, Jutta; Buffa, Francesca M; McDermott, Ultan; Tarsounas, Madalena

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology

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