Inhibition of the Wnt/Β-catenin pathway by the WWOX tumor suppressor protein
Oncogene, ISSN: 0950-9232, Vol: 28, Issue: 28, Page: 2569-2580
2009
- 89Citations
- 33Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations89
- Citation Indexes89
- 89
- CrossRef80
- Captures33
- Readers33
- 33
Article Description
The WWOX gene encodes a candidate tumor suppressor protein (WWOX) implicated in a variety of human diseases such as cancer. To better understand the molecular mechanisms of WWOX action, we investigated novel partners of this protein. Using the two-hybrid system and a coimmunoprecipitation assay, we observed a physical association between WWOX and the Dishevelled protein (Dvl) family signaling elements involved in the Wnt/Β-catenin pathway. We found that enforced WWOX expression inhibited, and inhibition of endogenous WWOX expression stimulated the transcriptional activity of the Wnt/Β-catenin pathway. Inhibition of endogenous WWOX expression also enhanced the effect of Wnt-3a on Β-catenin stability. Moreover, we observed the sequestration of Dvl-2 wild type and Dvl-2NESm, a mutated form of Dvl-2 predominantly localized in the nucleus, in the cytoplasm compartment by WWOX. Our results indicate that WWOX is a novel inhibitor of the Wnt/Β-catenin pathway. WWOX would act, at least in part, by preventing the nuclear import of the Dvl proteins. © 2009 Macmillan Publishers Limited.
Bibliographic Details
Springer Science and Business Media LLC
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