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Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell lymphoma: A retrospective study from the EBMT Lymphoma Working Party

Bone Marrow Transplantation, ISSN: 1476-5365, Vol: 53, Issue: 5, Page: 617-624
2018
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Studies from University Hospital Describe New Findings in Mantle Cell Lymphoma (Long-term outcome analysis of reduced-intensity allogeneic stem cell...

Studies from University Hospital Describe New Findings in Mantle Cell Lymphoma (Long-term outcome analysis of reduced-intensity allogeneic stem cell transplantation in patients with mantle cell

Article Description

Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%. Non-relapse mortality (NRM) was 10% at 100 days and 24% at 1 year and was lower for patients receiving anti-thymocyte globulin (ATG)/ALG (RR 0.59, p = 0.046). After a median follow-up of 72 months (range 3-159), 118 patients relapsed at a median of 8 months post RIST (range 1-117). The cumulative incidence of relapse was 25% and 40% at 1 and 5 years, respectively, and was associated with chemorefractory disease (HR 0.49, p = 0.01) and the use of CAMPATH (HR 2.59, p = 0.0002). The 4-year progression-free survival rate and overall survival rate was 31 and 40%, respectively. RIST results in long-term disease-free survival in about 30% of the patients, including those patients relapsing after a prior autoSCT.

Bibliographic Details

Robinson, Stephen P; Boumendil, Ariane; Finel, Herve; Peggs, Karl S; Chevallier, Patrice; Sierra, Jorge; Finke, Jürgen; Poiré, Xavier; Maillard, Natacha; Milpied, Noël; Yakoub-Agha, Ibrahim; Koh, Mickey; Kröger, Nicolaus; Nagler, Arnon; Koc, Yener; Dietrich, Sascha; Montoto, Silvia; Dreger, Peter

Springer Science and Business Media LLC

Medicine

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