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Secondary KIT mutations: the GIST of drug resistance and sensitivity

British Journal of Cancer, ISSN: 1532-1827, Vol: 120, Issue: 6, Page: 577-578
2019
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Article Description

Pharmacological targeting of KIT in gastrointestinal stromal tumours has dramatically changed the clinical outcome of this disease. Tyrosine kinase inhibitors are the cornerstone of this improvement, but resistance occurs through secondary KIT mutations. Studies aimed at improving our understanding of the molecular basis of sensitivity and resistance will soon allow us to further tailor our therapeutic strategies.

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