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Detecting adaptive changes in gene copy number distribution accompanying the human out-of-Africa expansion

Human Genome Variation, ISSN: 2054-345X, Vol: 11, Issue: 1, Page: 37
2024
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Article Description

Gene copy number variation can influence evolution and adaptation. This study uses modeling and simulations to investigate these forces’ impact on CNV in human populations. The method combines real data analysis with simulations of human population history and genetic evolution, highlighting the importance of both historical events and survival pressures in shaping gene copy numbers. The results suggest that changes in gene copy numbers across different populations can not be fully explained by population history alone, implying that adaptive changes in survival pressures also play a key role. Specifically, genes related to diet and immune response show significant variations, suggesting a possible link to dietary habits and disease resistance. The study concludes that both population shifts and natural selection have influenced human genetic diversity, with survival changes contributing significantly to the observed variations in gene copy numbers. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

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