Genome-wide systematic identification of methyltransferase recognition and modification patterns
Nature Communications, ISSN: 2041-1723, Vol: 10, Issue: 1, Page: 3311
2019
- 20Citations
- 95Captures
- 4Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations20
- Citation Indexes19
- 19
- CrossRef13
- Patent Family Citations1
- 1
- Captures95
- Readers95
- 95
- Mentions4
- News Mentions4
- 4
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Mystery of DNA methylation uncovered by scientist in Denmark
To a large extent, DNA methylation, which regulates vital cell functions, is still a mystery to the scientific world. Now, scientists have developed a method to quickly couple methylation enzymes to their respective methylation pattern. This finding could become essential for successful gene engineering in many species. All species mark their DNA with methyl groups. This is done to regulate gene e
Article Description
Genome-wide analysis of DNA methylation patterns using single molecule real-time DNA sequencing has boosted the number of publicly available methylomes. However, there is a lack of tools coupling methylation patterns and the corresponding methyltransferase genes. Here we demonstrate a high-throughput method for coupling methyltransferases with their respective motifs, using automated cloning and analysing the methyltransferases in vectors carrying a strain-specific cassette containing all potential target sites. To validate the method, we analyse the genomes of the thermophile Moorella thermoacetica and the mesophile Acetobacterium woodii, two acetogenic bacteria having substantially modified genomes with 12 methylation motifs and a total of 23 methyltransferase genes. Using our method, we characterize the 23 methyltransferases, assign motifs to the respective enzymes and verify activity for 11 of the 12 motifs.
Bibliographic Details
Springer Science and Business Media LLC
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