Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives.

Citation data:

Scientific reports, ISSN: 2045-2322, Vol: 7, Issue: 1, Page: 1720

Publication Year:
2017
Usage 2
Abstract Views 2
Captures 4
Readers 4
Mentions 1
References 1
PMID:
28496208
DOI:
10.1038/s41598-017-01950-7
Author(s):
Payne, Daniel T; Zhao, Yiming; Fossey, John S
Publisher(s):
Springer Nature
Tags:
Multidisciplinary
article description
Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11-67% yield from aldehydes. Aldehydes were reacted with Meldrum's acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.